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Dernières publications
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Dylan Moutachi, Janek Hyzewicz, Pauline Roy, Mégane Lemaitre, Damien Bachasson, et al.. Treadmill running and mechanical overloading improved the strength of the plantaris muscle in the dystrophin‐desmin double knockout (DKO) mouse. The Journal of Physiology, In press, ⟨10.1113/JP286425⟩. ⟨hal-04643936⟩
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Medhi Hassani, Dylan Moutachi, Mégane Lemaitre, Alexis Boulinguiez, Denis Furling, et al.. Beneficial effects of resistance training on both mild and severe mouse dystrophic muscle function as a preclinical option for Duchenne muscular dystrophy. PLoS ONE, 2024, 19, ⟨10.1371/journal.pone.0295700⟩. ⟨hal-04501283⟩
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Antonio Atalaia, Dagmar Wandrei, Nawel Lalout, Rachel Thompson, Adrian Tassoni, et al.. EURO-NMD registry: federated FAIR infrastructure, innovative technologies and concepts of a patient-centred registry for rare neuromuscular disorders. Orphanet Journal of Rare Diseases, 2024, 19 (1), pp.66. ⟨10.1186/s13023-024-03059-3⟩. ⟨hal-04460667⟩
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Florent Porquet, Lin Weidong, Kévin Jehasse, Hélène Gazon, Maria Kondili, et al.. Specific DMPK-promoter targeting by CRISPRi reverses myotonic dystrophy type 1-associated defects in patient muscle cells. Molecular Therapy - Nucleic Acids, 2023, 32, pp.857 - 871. ⟨10.1016/j.omtn.2023.05.007⟩. ⟨hal-04287597⟩
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Caroline Le Guiner, T Larcher, A Lafoux, G Toumaniantz, S Webb, et al.. Characterization of the muscular and cardiac diseases of the DMSXL mouse model, a transgenic mouse model for Myotonic Dystrophy type 1. American Society of Gene & Cell Therapy, May 2023, LOS ANGELES, United States. ⟨hal-04096181⟩
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Dylan Moutachi, Mégane Lemaitre, Clément Delacroix, Onnik Agbulut, Denis Furling, et al.. Valproic acid reduces muscle susceptibility to contraction‐induced functional loss but increases weakness in two murine models of Duchenne muscular dystrophy. Clinical and Experimental Pharmacology and Physiology, In press, ⟨10.1111/1440-1681.13804⟩. ⟨hal-04146953⟩
Chiffres clés
137
Publications avec texte intégral
Open Access
53 %
Mots clés
Transgenic mouse model
Muscle
Centronuclear myopathy
Motoneuron
Mouse model
Gene editing
PacBio
Gene Therapy
Myotonic dystrophy mouse models
MBNL
Therapy
Trinucleotide Repeat Expansion
DMSXL mice
Expression
Aging
Heart failure
CTG repeats
Cell penetrating peptide
Central nervous system
Desmin
Astrocyte
Duchenne muscular dystrophy
Autophagy
Dilated cardiomyopathy
Muscular dystrophy
RNA biology
KNOCKOUT MICE
Knockout
Endurance training
CMS
DMPK
Glutamate
Acute coronary syndrome
Myotonic Dystrophy
Dystrophin
GSK3
Acetylcholinesterase knockout mouse
Exercice
Fibrosis
DM1
Quantitative microdialysis
CRISPR/Cas9
Hypoxia
Brain
Myostatin
Glucocorticoid-receptor
RNA interference
Diaphragm
ACETYLCHOLINESTERASE
GABA
Humans
Neuron
Acetylcholinesterase deficiency
Intermediate filament
Cytoskeleton
Astrocytes
Glucocorticoids
Transgenic mouse
AAV
Animals
Cell culture model
Myotonic dystrophy
Antisense oligonucleotides
Oligodendrocyte
In vivo
ARN
Myotonic Dystrophy Type 1
Thérapie génique
Genotype phenotype correlation
Long read sequencing
PCR
CONGENITAL MYATHENIC SYNDROME
Dystrophie Myotonique
Antisense oligonucleotide
Heart
Myelin
Oligodendrocytes
Alternative splicing
Mice
Skeletal muscle
Brain dysfunction
RNA splicing
Transcriptomics
Cell model
Myotonic Dystrophy type 1
Maximal force
CTG repeat contractions
Dynamin 2
Dystrophie myotonique
CTG repeat instability
Gene therapy
BIOLOGIE MOLECULAIRE
Trinucleotide repeat expansion
Exercise
Male
CRISPRi
Cardiac muscle
Glial cells
Mouse models
Myotonic dystrophy type 1