Corpus callosum damage to account for cognitive, affective, and social-cognitive dysfunctions in multiple sclerosis: A model of callosal disconnection syndrome? - Université catholique de Lille
Article Dans Une Revue Multiple Sclerosis Journal Année : 2023

Corpus callosum damage to account for cognitive, affective, and social-cognitive dysfunctions in multiple sclerosis: A model of callosal disconnection syndrome?

Résumé

The corpus callosum (CC) is the major commissure interconnecting the two hemispheres and is particularly affected in multiple sclerosis (MS). In the present review, we aimed to investigate the role played by callosal damages in the pathogenesis of MS-related dysfunctions and examine whether a model of callosal disconnection syndrome is a valid model for MS. For this purpose, we will first review structural and functional evidence of callosal pathology in MS. Second, we will account for the potential role of CC abnormalities in MS-related dysfunctions. Finally, we will report data concurring with a “multiple disconnection hypothesis” that has been proposed to explain those dysfunctions, and we will examine evidence pointing toward MS as a “callosal disconnection syndrome.” We will end by discussing the contribution of this interpretation to the understanding of MS and MS-related deficits.
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Dates et versions

hal-04204926 , version 1 (12-09-2023)

Identifiants

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Béatrice Degraeve, Henrique Sequeira, Halima Mecheri, Bruno Lenne. Corpus callosum damage to account for cognitive, affective, and social-cognitive dysfunctions in multiple sclerosis: A model of callosal disconnection syndrome?. Multiple Sclerosis Journal, 2023, 29 (2), pp.160-168. ⟨10.1177/13524585221091067⟩. ⟨hal-04204926⟩
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