Impact of information processing speed on episodic memory in multiple sclerosis: a survival analysis - Université catholique de Lille
Poster De Conférence Année : 2022

Impact of information processing speed on episodic memory in multiple sclerosis: a survival analysis

Résumé

In learning assessment, time limits or fixed number of trials make it difficult to distinguish between the effect of reduced cognitive ability and lack of time to complete the task. Our study proposes to use time-to-event data approach to address this issue. Survival analysis focuses on the time until a particular event occurs (recall the total word’s list) and appears appropriate to characterize the progression of learning in EM task (SRT, requiring to recall a 15 words list twice consecutively) in RRMS- and PPMS-patients compared to controls. We examined recall performances on the SRT in 157 MS-patients and 157 controls. 31% of patients manage to recall the entire list of words, twice consecutively, compared to 79% of controls. The median survival times decreased from 9-trials in patients to 8-trials in controls, indicating that controls achieved the recall on two consecutive trials sooner than patients. Learning curves analysis showed an increasing linear trend for patients, suggesting that more and more patients completed the task as trials progress. Survival analysis provides a complementary assessment of EM to the traditional paradigm, and an innovative way to address slow-learning in MS. This study underlines a possible beneficial effect of extra-time on learning performance.
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Dates et versions

hal-04205184 , version 1 (12-09-2023)

Identifiants

  • HAL Id : hal-04205184 , version 1

Citer

Bruno Lenne, Clémentine Luneau, Delphine Fleurion, Halima Mecheri, Béatrice Degraeve. Impact of information processing speed on episodic memory in multiple sclerosis: a survival analysis. International Multiple Sclerosis Cognition Society (IMSCOG), May 2022, Bordeaux (France), France. ⟨hal-04205184⟩
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